动物基质中的抗病毒药物:一篇综述
Samantha Sasse1, Ane Arrizabalaga-Larrañaga1, Saskia S Sterk1
1Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, European Union Reference Laboratory for Residues, 6700 AE, Wageningen, the Netherlands.
Heliyon
|September 23, 2024
概括
在食品动物中滥用抗病毒药物需要新的分析方法来确保食品安全. 本次审查确定了关键的病毒,药物和矩阵,突出了食品控制实验室有效监测数据缺口.
科学领域:
- 食品安全和兽医 动物医学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 食品生产动物的抗病毒药物使用越来越受限制,需要强大的分析方法进行官方控制.
- 非洲猪瘟和禽流感等动物病毒造成的重大经济损失促使人们寻找替代治疗方法.
- 人类抗病毒药物的滥用,如家禽中的阿曼塔丁,由于治疗缺陷而被观察到.
研究的目的:
- 审查相关的病毒,抗病毒药物和动物衍生矩阵,用于食品控制中的分析方法开发.
- 提供对欧盟内生产食品动物抗病毒药物残留物监测的见解.
- 识别阻碍有效的官方控制的知识差距.
主要方法:
- 在动物衍生矩阵 (查试验,传感器,质谱) 中对抗病毒药物的分析方法的文献综述.
- 对2012-2023年期间公布的数据进行分析,重点关注方法开发和应用.
- 确定与食品安全相关的关键抗病毒药物类别和动物矩阵.
主要成果:
- 有各种分析方法可用于检测抗病毒药物,包括质谱.
- 关于药理动力学,代谢物形成和动物组织中的分布的信息通常是不完整的.
- 在全球范围内,关于动物基因基因组中不同抗病毒药物的滥用数据很少.
结论:
- 在食品动物中有效监测抗病毒药物需要处理不完整的药理动力学数据和有限的滥用信息.
- 需要优先考虑分析范围,专注于关键的抗病毒药物类别和像肌肉这样的矩阵.
- 进一步的研究对于支持监管合规和确保食品安全至关重要.
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