在多种癌症中与铁亡相关的氧沙抗性:潜在的作用和治疗影响
Sijia Zhong1, Zihan Wang2, Jiaxi Yang1
1Department of Gastrointestinal Surgery, the First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.
Heliyon
|September 23, 2024
概括
在癌症中,可通过向细胞死亡途径铁死来克服氧沙的耐药性. 增强铁或将其与oxaliplatin结合,有望改善癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 奥克萨利普拉丁 (OXA) 是一种关键的化疗药物,但耐药性是一个主要的临床障碍.
- 铁,一种依赖于铁的细胞死亡,与OXA抵抗有关,特别是通过SLC7A11-GPX4轴和Nrf2调节.
- 像LINC01134和DACT3-AS1这样的长非编码RNAs (lncRNAs) 在各种癌症中调节铁和OXA敏感性.
研究的目的:
- 审查铁质在抗氧化抗药性中的作用.
- 突出将铁亡途径 (SLC7A11-GPX4, Nrf2, lncRNAs) 与CRC,HCC和胃癌等癌症中的OXA耐药性联系起来的分子机制.
- 总结针对铁亡的治疗策略,以克服OXA耐药性.
主要方法:
- 关于抗氧化耐药性,铁死和癌症的研究文献综述.
- 对参与铁灭调节的分子通路的分析,包括SLC7A11-GPX4,Nrf2和特定的lncRNAs (LINC01134,DACT3-AS1).
- 检查针对铁亡的治疗干预措施,以逆转化疗抵抗.
主要成果:
- SLC7A11-GPX4系统和Nrf2的调节失调是OXA抵抗的一个常见机制.
- 特定的lncRNAs,LINC01134和DACT3-AS1,被确定为铁亡的调节者,分别影响HCC和胃癌中的OXA敏感性.
- 对铁亡途径的遗传或药物抑制可以逆转OXA耐药性.
结论:
- 铁死在多种癌症类型中对氧化抗性起着关键作用.
- 通过抑制关键调节剂或与OXA结合治疗来向铁亡,提供了一种有前途的战略,以克服化学抵抗.
- 对基于铁灭的治疗方法的进一步研究可能会导致OXA耐药癌症的新型治疗方法.
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