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初级乳腺黑色素瘤是一个真正的病理实体吗? 对它的论点,对它的论点
Alexis R Narvaez-Rojas1,2, Samantha Linhares3, Shaina Sedighim4
1Department of Radiation Oncology, Maimonides Cancer Center, Brooklyn, NY, USA.
Heliyon
|September 23, 2024
概括
乳腺外围膜的原发性黑色素瘤 (PMBP) 是罕见的,通常是由转移性传播引起的. 有效的管理涉及多学科护理,包括手术和免疫疗法,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 乳腺外围膜的原发性黑色素瘤 (PMBP) 是一种罕见的实体,其致病性不明.
- 之前的研究已经记录了病例,但对其呈现和结果缺乏全面的理解.
- 本研究回顾了现有文献,并提出了新的病理分析,以阐明PMBP.
研究的目的:
- 审查乳腺帕伦基马病例中报告的原发性黑色素瘤的临床表现和结果.
- 为另外四个病例提供详细的病理分析.
- 讨论这种情况的潜在病原遗传理论.
主要方法:
- 对29项已发表的研究 (95名患者) 的系统综述.
- 包括四个新患者病例,共99名患者.
- 分析患者人口统计数据,以前的黑色素瘤病史,瘤位置,结节状况,治疗方法和生存数据.
主要成果:
- 该研究发现了99例病例,主要是女性 (92%),平均年龄为50岁.
- 很大一部分 (56%) 有皮肤黑色素瘤的病史,通常在干部或四肢.
- 结节转移 (40.3%) 和远程转移性疾病 (30%) 在呈现时很常见,平均存活时间为11.5个月.
结论:
- 乳腺膜性黑色素瘤可能是已知或未知的原发性皮肤黑色素瘤的转移性病变,不是真正的PMBP.
- 多学科的方法对于管理至关重要.
- 治疗应包括带有负边缘的外科切除,为阳性节点进行淋巴切除,以及新辅助/辅助免疫疗法.
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