与结核病相比,在沙丘病中血清干扰素活性增加:对诊断的影响?
Benjamin Schrijver1, Jens Göpfert2, Rina La Distia Nora3
1Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center Rotterdam, the Netherlands.
Heliyon
|September 23, 2024
概括
结核病 (TB) 患者的血清干扰素 (IFN) 水平低于类病患者的水平. 测量IFN水平和活性可能有助于区分这些类似疾病,包括它们的脑膜炎形式.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
背景情况:
- 麻症和结核病 (TB) 呈现类似的临床症状,使得差异诊断具有挑战性.
- 干扰素 (IFN) 在免疫反应中起着至关重要的作用,但其在肉病和结核病病理生理学中的具体作用尚未完全理解.
- 了解IFN的作用可以确定区分这些疾病的生物标志物.
研究的目的:
- 测量血清干扰素 (IFN) 度和活性,在患有沙丘病和结核病的患者.
- 调查IFN作为沙丘病和结核病之间的区分标记物的潜力,特别是在脑膜炎的情况下.
- 探索IFN在这些条件下独特的病理生理学作用.
主要方法:
- 分析了来自印度尼西亚结核病和荷兰肉类发病队伍的血清样本.
- 干扰素α2 (IFNα2) 和干扰素γ (IFNγ) 度使用Simoa®和Luminex试验量化.
- 血清IFN活性通过在血清化后测量IFN刺激的THP-1细胞中的基因转录来评估.
主要成果:
- 在肉病患者中,IFNα2和IFNγ的检测频率高于结核病患者.
- 与结核性脑膜炎 (TBU) 相比, Sarcoid 脑膜炎 (SU) 的血清 IFNα2 和 IFNγ 水平显著更高.
- 与健康对照组相比,结核病患者的血清IFNα2度降低,同时增加非中和抗IFN自身抗体.
结论:
- 在结核病中观察到I型和II型IFN的血清度和活性下降,而非类型的结核病.
- 涉及IFN的明确的病理生理机制可能是萨尔科毒症和结核病的基础.
- 血清IFN评估有可能区分沙尔科毒症/SU与结核病/TBU.
更多相关视频
15:57Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
12.2K
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13.3K
相关概念视频
Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
Pulmonary Tuberculosis I
224
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
224
Pulmonary Tuberculosis III
312
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
312
Pulmonary Tuberculosis II
213
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
213
