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Updated: Jun 12, 2025

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
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以MCT1为媒介的内皮细胞乳酸穿作为促进脊髓损伤后轴突再生的目标

Chaoran Shi1,2,3, Jiaqi Xu1,2,3, Yinghe Ding1,2,3

  • 1Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.

Theranostics
|September 23, 2024
PubMed
概括

在脊髓损伤 (SCI) 后,通过MCT1在内皮细胞中恢复乳酸运输促进了小鼠的轴突再生和功能恢复. 这突出了SCI治疗的新代谢标.

关键词:
轴突再生的重生作用细胞内皮细胞的内皮细胞.乳酸穿机 乳酸穿机神经元代谢的神经元代谢脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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