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相关概念视频

Viral Mutations00:36

Viral Mutations

32.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.2K
Mutations01:35

Mutations

34.8K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
34.8K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

14.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.8K
Viral Recombination00:57

Viral Recombination

23.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.3K
Mismatch Repair01:20

Mismatch Repair

4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.0K

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相关实验视频

Updated: Jun 12, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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COVID-19突变:一个概述

Malay Sarkar1, Irappa Madabhavi2,3

  • 1Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla 171001, Himachal Pradesh, India.

World journal of methodology
|September 23, 2024
PubMed
概括
此摘要是机器生成的。

严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 继续演变,导致像Omicron这样的新变种. 这些突变会影响感染性,传染性和疫苗的有效性,造成持续的公共卫生挑战.

关键词:
在E484K突变中.N501Y突变是一种突变.这就是Omicron.这就是SARS-CoV-2病毒.有关关注的变种.

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

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相关实验视频

Last Updated: Jun 12, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

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科学领域:

  • 病毒学和分子生物学
  • 传染性疾病 传染性疾病
  • 公共卫生 公共卫生

背景情况:

  • 严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2),一种贝塔冠状病毒,是导致当前大流行的原因.
  • 常见的人类冠状病毒导致季节性呼吸道感染,但SARS-CoV-2,MERS-CoV和SARS-CoV具有高度致病性.
  • 由疫苗接种和先前感染的免疫压力等因素驱动的病毒进化导致SARS-CoV-2的突变.

研究的目的:

  • 审查SARS-CoV-2的各种突变,重点关注关注的变种 (VOC).
  • 分析这些突变对病毒感染性,传播性和中和效能的影响.
  • 了解突变对诊断测试准确性和临床管理的影响.

主要方法:

  • 在PubMed,EMBASE,Covariant,斯坦福变种数据库和CINAHL的系统文献搜索.
  • 包括从2019年12月到2023年2月的研究.
  • 搜索术语包括"VOC"",SARS-CoV-2"",Omicron"和"SARS-CoV-2中的突变".

主要成果:

  • 在全球范围内出现了几个令人担忧的SARS-CoV-2变种 (VOC),包括Alpha,Beta,Delta,Gamma和Omicron.
  • 突变,特别是尖端蛋白的突变,可以增强感染性和传染性.
  • 这些突变可能会降低抗体 (单克隆,康复期,疫苗诱导) 中和的疗效,并影响诊断测试检测.

结论:

  • SARS-CoV-2 突变显著影响其生物特性和临床影响.
  • 持续的病毒进化需要对变种及其特征进行持续监测.
  • 突变对诊断,治疗和控制策略构成挑战,突出显示了对适应性公共卫生反应的需要.