瘤沉积作为第三阶段结肠癌的不良预后指标:一个多中心数据库研究
Jeeyou Kim1, Dong Woon Lee2, Ji Won Park1,3,4
1From the Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
概括
瘤沉积 (TDs) 显著恶化结肠癌的预后和生存率. 在结节阶段 (N1a/b至N2) 中重新分类TD阳性病例可以提高当前分期的准确性,以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 癌症的分期 癌症的分期
- 结肠直肠癌研究研究
背景情况:
- 目前美国癌症分期联合委员会将瘤沉积物 (TD) 分类为N1c.
- 节点分期 (N1a/b,N2a/b) 目前优先考虑淋巴结转移 (LNMs) 而不是TDs.
研究的目的:
- 研究瘤沉积物 (TD) 在结肠癌中的瘤影响.
- 建议对结肠癌分期系统进行修改,以提高准确性.
主要方法:
- 分析了来自首尔结肠直肠组的4212名患者和来自SEER数据库的93,057名患者.
- 根据淋巴结转移 (LNs) 和TDs的存在进行分类.
主要成果:
- 与左结肠癌相关的TDs,较高的T类别,以及血管/围神经入侵.
- 呈TD阳性患者的复发率显着更高 (23.1%对7.5%),整体存活率 (OS) 和无复发存活率更差.
- 对TD阳性患者的生存结果与TD阴性患者的生存结果相似,结节负担较高.
结论:
- 瘤沉积是影响结肠癌存活率的显著负面预后因素.
- 将TD集成到N1c以外的节点分类中可能会提高分期精度.
- 将TD阳性N1a或N1b病例重新分类为N2可以更好地反映患者的预后.
更多相关视频
相关概念视频
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K