布里奥菲勒姆皮纳塔姆 (拉姆语) 是一种植物. 奥肯:揭开治疗潜力和导航毒性的毒性
Garima Sharma1, Alka Jangra2, Sonia Sihag1
1Department of Biotechnology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana India.
概括
一种药用草药Bryophyllum pinnatum显示出治疗癌症,结石和糖尿病的潜力. 然而,由于bufadienolides的潜在毒性,需要进行研究来证实其药用益处和安全性.
科学领域:
- 民族植物学 民族植物学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 布里奥菲勒姆皮纳图姆 (Lam.) 是一种植物. 奥肯是一种被广泛认可的药用草本.
- 它的治疗性质归因于各种二次代谢物,如布法类,黄类和类.
- 传统和现代医学系统对其治愈潜力表现出兴趣.
研究的目的:
- 审查Bryophyllum pinnatum的多方面的治疗应用.
- 探索其在瘤学,,糖尿病和COVID-19研究中的潜力.
- 强调需要对其机制和安全进行进一步调查.
主要方法:
- 关于Bryophyllum pinnatum的科学研究的文献综述.
- 对植物化学成分及其药理作用的分析.
- 检查传统用途和科学验证.
主要成果:
- 布里奥菲勒姆皮纳图姆 (Bryophyllum pinnatum) 具有抗癌,抗,抗糖尿病,抗莱什曼病,神经药物学,抗菌,免疫抑制和细胞毒性作用.
- 这种草药含有布法迪化物,这有助于其有效性,但也引起了毒性问题.
- 指出了和肝脏疾病以及与COVID-19有关的潜在应用.
结论:
- 布里奥菲勒姆皮纳图姆在各种医学领域具有显著的治疗潜力.
- 进一步的研究对于阐明其分子机制,药理动力学和安全性概况至关重要.
- 需要进行全面的研究,以确保安全使用这种多功能药用草本.
相关概念视频
01:13Therapeutic Index
4.1K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.1K
01:24Antiasthma Drugs: Methylxanthines
206
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
206
01:24Tissue-Drug Binding: Localization of Drugs and its Significance
72
Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...
72
01:21Drug Distribution: Tissue Binding
2.6K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
For...
2.6K