在结核病流行环境中持续的Mycobacterium结核病生物气溶释放
Ryan Dinkele1,2, Sophia Gessner1,2, Benjamin Patterson3
1UCT Molecular Mycobacteriology Research Unit, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
iScience
|September 23, 2024
概括
结核菌菌 (Mtb) 是由社区中的许多个人释放的,而不仅仅是那些患有活跃结核病的人. 这一发现挑战了关于结核病传播和病因学的传统观点.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 从历史上看,人们认为结核病 (TB) 传播需要症状性疾病和活跃的Mycobacterium tuberculosis (Mtb) 释放.
- 这种范式表明病理是Mtb传播的先决条件.
研究的目的:
- 在结核病流行社区调查Mtb生物气溶释放情况.
- 质疑假设,只有有症状的结核病患者才能传播mtb.
主要方法:
- 在结核病流行地区招募了89名社区成员进行随机抽样.
- 在2个月内对50个人进行了纵向抽样.
- 评估了含有Mtb的生物气溶释放和QuantiFERON状态.
主要成果:
- 79.8%的随机招募的社区成员释放了含有Mtb的生物气溶.
- 释放是独立于QuantiFERON状态 (Mtb暴露的标志物).
- 在2个月的随访期间,只有2%的个体连续呈 Mtb 生物气溶阴性.
结论:
- 广泛的Mtb释放发生在结核病流行社区,而不管确诊的结核病或Mtb暴露.
- 这就需要在理解MTB传播和结核病病因学方面进行范式转变.
- 这些发现可能解释了结核病流行地区结核病传播网络绘制的困难.
关键词:
微生物学 微生物学相关概念视频
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