锡利宾:对其针对性和新型药物的审查,以治疗基于病变发生的肝脏疾病
Jijiao Wu1,2, Lin Wen1,2, Xiaolian Liu1,2
1State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Phytotherapy research : PTR
|September 23, 2024
概括
由于其有益的特性,西利宾在治疗肝脏疾病方面表现有前途. 新型配方和纳米技术正在改善其低溶解度和生物可用性,以便在肝病治疗中更好地临床应用.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
背景情况:
- 肝病是全球主要的健康问题.
- 来自Silybum marianum的西利宾具有抗炎,抗氧化,抗纤维,抗病毒和细胞保护性质.
- 西利宾是治疗各种肝病的潜在疗法,包括纤维化,肝硬化,癌症,病毒性肝炎和NAFLD.
研究的目的:
- 审查最近关于西利宾用于治疗肝病的研究.
- 专注于针对疾病发病的新型西利宾配方.
- 探索以纳米技术为基础的方法,以提高西利宾的生物可用性和可溶性.
主要方法:
- 关于肝病中的西利宾研究的综合文献综述.
- 对新型西利宾配方 (例如CD44受体,叶酸,维生素A向) 的分析.
- 检查纳米技术应用 (纳米颗粒,脂质体,纳米悬浮体) 以改进silybin交付.
主要成果:
- 西利宾在一系列肝脏疾病中显示出治疗潜力.
- 新的配方和基于纳米技术的方法显示出在克服silybin的局限性方面具有前景.
- 为了提高有效性,研究了各种向传递系统和纳米载体.
结论:
- 西利宾配方,特别是那些通过纳米技术增强的配方,代表了肝脏疾病治疗的有希望的途径.
- 需要进一步进行高质量的研究,才能充分确定这些制剂的疗效和安全性.
- 在西利宾配方研究中的挑战需要继续进行调查.
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:30siRNA - Small Interfering RNAs
16.6K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.6K
01:26Targets for Drug Action: Overview
6.1K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.1K