开发基于四级的烯基共聚合物抗微生物涂层,用于聚氨气管食管口腔语音假体
Manjeet Singh1, Aiman Afreen1, Mohd Anees1
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi-110016, India. harpal2000@yahoo.com.
Journal of materials chemistry. B
|September 23, 2024
概括
研究人员开发了一种新的抗微生物涂层,用于气管食道语音假体 (TEP),以防止生物膜形成并延长设备寿命. 这种创新的涂层提供了针对微生物污染的增强保护,改善了全喉切除术后患者的生活质量.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 医疗器械涂层 医疗器械涂层
背景情况:
- 气管食管声假体 (TEP) 在全喉切除术 (TL) 后的语音恢复中至关重要.
- 在TEP上形成生物膜会导致设备故障,需要频繁更换,影响患者的生活质量.
- 由于微生物殖民和生物膜的发展,目前的TEP的寿命有限.
研究的目的:
- 为TEPs开发一种新的阴离子抗菌涂层,以防止生物膜的形成.
- 通过接触杀死抗微生物活性来增强TEP的功能寿命.
- 评估开发的涂层的安全性,机械性和抗菌疗效.
主要方法:
- 通过自由基聚合,合成一种基于烯酸盐的四聚合物 (poly(MMA-co-BA-co-DMAEMA-co-HEMA)).
- 使用六甲基二酸 (THDI) 三合剂对共聚物进行交叉连接,然后进行四合化.
- 涂层变体的表征和测试细胞相容性,血液相容性,机械性质,以及对大肠杆菌,黄金色杆菌和白杆菌的抗菌疗效.
主要成果:
- 一种特定的四聚合物组成 (22.5%MMA,22.5%BA,20%HEMA,35%DMAEMA) 显示出最佳的结果.
- 开发的阴离子抗菌涂层表现出极好的细胞相容性和血液相容性.
- 该涂层在最多180天内保持了对常见微生物病原体的显著抗微生物特性.
结论:
- 开发的阴离子交联抗微生物涂层有效地防止TEP表面的生物膜形成.
- 这种创新的涂层显著提高了语音假肢的耐用性和功能寿命.
- 这项研究提出了一项有希望的策略,以改善接受全喉切除术的患者的治疗结果.
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