预测韩国从未吸烟者肺癌与多基因风险评分的肺癌
Juyeon Kim1, Young Sik Park2, Jin Hee Kim3
1Department of Public Health Sciences, Seoul National University, Seoul, Korea.
Genetic epidemiology
|September 23, 2024
概括
这项研究开发了一种针对韩国从未吸烟者使用多基因风险评分 (PRS) 的肺癌风险预测模型. 纳入PRS的模型证明了预测准确度的提高,强调PRS是评估肺癌风险的有价值工具.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 全基因组关联研究 (GWAS) 已经确定了许多肺癌易感位置.
- 这些已识别的位点对于开发先进的癌症风险预测工具至关重要.
研究的目的:
- 专门为韩国从未吸烟者开发一个肺癌风险预测模型.
- 在这个预测模型中评估多基因风险得分 (PRS) 的实用性.
主要方法:
- 使用修剪值方法计算的多基因风险得分 (PRS) 具有11个全基因组显著单核酸多态 (SNP).
- 开发了一种结合PRS的肺癌预测模型.
- 使用接收器运行特征 (ROC) 曲线和DeLong测试,与PRS和没有PRS的预测模型性能进行比较.
主要成果:
- 较高的PRS与肺癌的几率比率增加有关.
- 在前5%的PRS群体中,与参考组相比,赔率比率为1.71.
- 预测模型实现了0.76的曲线下面积 (AUC),表明了显著的预测能力.
- 在带有PRS和没有PRS的模型之间观察到预测性能的显著差异.
结论:
- 多基因风险评分 (PRS) 对于预测韩国从未吸烟者的肺癌风险非常有价值.
- 开发的基于PRS的模型提供了更好的肺癌风险预测准确度.
- 这项研究支持将PRS纳入肺癌临床风险评估策略.
相关概念视频
Statistical Methods for Analyzing Epidemiological Data
316
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
316
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Relative Risk
123
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
123


