在长期COVID-19患者中,小气道功能障碍和肺高通胀是持续性呼吸障碍的潜在机制
Angelos Vontetsianos1, Nikolaos Chynkiamis1,2, Christina Anagnostopoulou1
1Rehabilitation Unit, 1st Respiratory Medicine Department, "Sotiria" Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
长期COVID-19患者在住院后经常经历小呼吸道功能障碍和肺部膨胀. 这些情况与持续的呼吸困难相关,影响了SARS-CoV-2感染后的恢复.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 由于SARS-CoV-2感染而住院的长期COVID-19幸存者可能会出现肺部异常,如网膜和支气管病变.
- 在长期COVID-19患者中,关于小呼吸道损伤和肺高通胀的数据仍然有限.
- 了解这些COVID-19后的呼吸系统后果对于患者管理至关重要.
研究的目的:
- 评估住院长期COVID-19患者的小气道功能.
- 为了评估这个队列中的肺高通胀的患病率.
- 为了确定这些呼吸系统障碍与COVID-19后呼吸困难之间的关联.
主要方法:
- 对33名住院的长期COVID-19患者 (平均年龄53岁) 进行了肺功能测试.
- 肺高通胀被定义为残留体积/肺总容量 (RV/TLC) ≥40%.
- 通过单呼吸清洗 (SBN2W) 评估了使用闭合体积 (CV) 和闭合容量 (CC) 的小气道功能.
主要成果:
- 在39%的患者中发现了闭合能力 (CC) 的异常,27%的患者表现出异常的开放能力 (OC).
- 15名患者患有肺高通胀,与CC (r=0.772),OC (r=0.895) 和呼吸困难严重程度有显著的相关性 (mMRC得分,r=0.444).
- 医学研究理事会 (mMRC) 修改后呼吸障碍得分的平均值为2.2表示明显的呼吸困难.
结论:
- 长期住院的COVID-19患者经常表现出小气道功能障碍.
- 肺部高通胀是这些患者的常见发现,与持续性呼吸障碍有关.
- 这些呼吸系统障碍有助于长期COVID-19幸存者所经历的持续呼吸困难.
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