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Updated: Jun 12, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

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PHF8/KDM7B:在神经系统疾病和癌症中,一种多功能质脱甲基酶和表观遗传修饰剂

Tingyu Fan1, Jianlian Xie2, Guo Huang1,3

  • 1Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang 421001, China.

Epigenomes
|September 23, 2024
PubMed
概括

植物同源域指蛋白8 (PHF8),一个关键的表观遗传调节器,对发育至关重要,并与神经发育障碍和癌症有关. 了解 PHF8 的理解

关键词:
在 PHF8/KDM7B 中.表观遗传学是指表观遗传学.氨酸脱甲基化是氨酸的脱甲基化.恶性瘤 恶性瘤神经系统疾病 神经系统疾病

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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