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相关概念视频

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

354
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
354
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

575
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
575
Menopause01:28

Menopause

145
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
145
Signs of Puberty01:27

Signs of Puberty

279
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
279
Infertility in Males01:23

Infertility in Males

255
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
255
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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相关实验视频

Updated: Jun 12, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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在男性的丸激素治疗的指示.

Mathis Grossmann1,2

  • 1Department of Medicine (Austin Health), The University of Melbourne, Melbourne.

Current opinion in endocrinology, diabetes, and obesity
|September 23, 2024
PubMed
概括

丸激素治疗有利于被诊断为阴性恋的男性. 对于老年男性,他们的丸激素和症状低,但没有明显的HPT轴疾病,最近的试验表明短期的好处,但长期的风险仍然未知.

科学领域:

  • 内分泌学 在内分泌学.
  • 男人的健康 男人健康
  • 安德罗学与人类学

背景情况:

  • 替代疗法 (TRT) 是建立在有机性低子症.
  • 在有症状的雄激素缺乏和低丸激素的老年男性中使用TRT,但没有明显的下丘脑-垂体-丸 (HPT) 轴疾病,仍在争论中.
  • 这种状况有时被称为"功能性"或"晚发"的阴性双胞胎症.

研究的目的:

  • 审查最近关于中年和老年男性有症状的雄激素缺乏症的丸激素治疗的益处和风险的数据.
  • 评估TRT对该群体各种健康参数的影响.

主要方法:

  • 对三项大型随机对照临床试验的综述.
  • 对有关性功能,活力,认知,情绪,葡萄糖代谢,身体功能,血液学参数,骨,心血管和前列腺健康等数据的分析.

主要成果:

  • 最近的试验提供了关于TRT在老年男性患有下腺症状的新短期到中期数据.
  • 观察到的效应涵盖性功能,活力,认知,情绪,新陈代谢,身体功能,以及血液,骨,心血管和前列腺健康.

结论:

  • 研究结果支持对中年和老年男性进行更个性化的TRT治疗方法.

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  • 在这个群体中,治疗的长期益处和风险 (超过3-4年) 仍然是未知的.