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在患有多发性硬化症的人群中,异常的视垂眼反射功能与平衡和行走障碍相关

Marco Tramontano^1,2, Laura Casagrande Conti³, Amaranta Soledad Orejel Bustos^3,4

¹Department of Biomedical and Neuromotor Sciences, University of Bologna, 40138 Bologna, Italy.

Audiology research

|September 23, 2024

概括

患有多发性硬化症 (MS) 的人往往在半圆形通道 (SCC) 中具有受损的角前庭眼反射 (aVOR). 这种障碍与临床平衡和步行障碍相关,特别是在残疾较大的人群中.

科学领域:

神经学神经学
静脉系统研究研究
临床评估临床评估

背景情况:

多发性硬化症 (MS) 是全球领先的自身免疫神经系统疾病.
平衡障碍是MS患者常见且显著的症状.
静脉系统功能障碍有助于MS相关的平衡障碍.

研究的目的:

在患有多发性硬化症的个体中,评估所有六个半圆通道 (SCC) 的角向前庭眼反射 (aVOR).
调查aVOR功能与已建立的临床平衡尺度之间的相关性.
确定头部冲动测试 (HIT) 范式是否可以揭示多发性硬化中的前置缺陷.

主要方法:

使用视频头部脉冲测试 (vHIT) 来测量每个SCC的aVOR增益.
进行的临床平衡评估:扩展残疾状态量表 (EDSS),伯格平衡量表 (BBS) 和迷你BEST (MBT).
招募了27名多发性硬化症患者 (平均年龄为47.93±8.51岁).

主要成果:

超过81%的参与者在至少一个SCC中表现出异常的aVOR增长.
在左前SCCaVOR增益和MBT和BBS分数之间发现了中等到强烈的相关性.
亚组分析显示,这种与BBS的相关性在MS患者中更明显,EDSS得分更高.

结论:

在多发性硬化症患者的多个SCC中,aVOR功能受损是常见的.
在垂直SCC中aVOR增益的降解与通过临床尺度测量的平衡和步态障碍有关.
vHIT提供了关于前庭功能障碍的宝贵见解,有助于MS相关的平衡问题.

关键词:

这是一个平衡的平衡,平衡的平衡.头部冲动测试试验测试多发性硬化症多发性硬化症康复康复康复康复康复康复技术技术的技术技术的技术.这是前置体前置体.

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