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在女性中持续的COVID-19后内皮功能障碍和氧化应激

Natalya Semenova¹, Ekaterina Vyrupaeva¹, Sergey Kolesnikov¹

¹Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk 664003, Russia.

Pathophysiology : the official journal of the International Society for Pathophysiology

|September 23, 2024

概括

COVID-19感染破坏了内皮功能和自由基平衡,导致持续的氧化应激和脂质过氧化. 这些变化有助于长期的COVID后疾病和相关病理.

科学领域:

生物医学科学生物医学科学
病理生理学病理生理学
氧化应激研究研究氧化应激研究

背景情况:

内皮功能障碍和改变的自由基平衡与各种病理有关.
COVID-19已与显著的系统性影响有关,包括潜在的长期后果.

研究的目的:

评估COVID-19和没有COVID-19的女性内皮功能障碍和自由基平衡.
调查急性COVID-19和无症状感染对氧化应激标志物的影响.
在COVID-19后12个月评估自由基平衡的长期变化.

主要方法:

评估了92名女性 (45-69岁) 的内皮功能障碍和自由基平衡参数.
分组参与者为:控制 (没有COVID-19),急性COVID-19,COVID-19后12个月,无症状COVID-19.
测量了谷氨过氧化酶 (GPx),超氧化解化酶 (SOD),谷氨减少酶 (GR),谷氨S转移酶pi (GSTpi) 的活性,以及高级糖化终产物 (AGEs),硫酸反应物 (TBARs),内甲素 (END) -1,END-2,8-OHdG,氧化谷氨 (GSSG),总抗氧化剂状态 (TAS),减少谷氨 (GSH) 和GSH/GSSG比率的水平.

主要成果:

与对照组相比,急性COVID-19患者的GPx和SOD较低,AGE降低,GR,GSTpi,TBAR,END-1和END-2较高.与对照组相比,急性COVID-19患者的GPx和SOD较低,AGE降低,GR,GSTpi,TBAR,END-1和END-2较高.
无症状的COVID-19组具有较低的8-OHdG,GSSG和TAS,但高的GSH和GSH/GSSG比率.
在COVID-19后的12个月里,高脂质过氧化产物持续存在,这表明长期的自由基失衡.

结论:

COVID-19 感染显著改变内皮功能和自由基平衡.
持续的氧化应激和COVID-19后的脂质过氧化可能会导致长期的后果.
了解这些机制对于管理COVID后的情况至关重要.

关键词:

在 COVID-19 疫情中,抗氧化剂的状态抗氧化剂的状态内皮质功能障碍在内皮质功能障碍更年期绝经绝经氧化应激是一种氧化应激.在COVID后的世界里.

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