精神疾病中的神经血管功能障碍:潜在的机制和治疗方法
Eliane Swely Sanches1,2,3,4, Daniela Simões1,2,3,4, Filipa Isabel Baptista1,2,3,4
1University of Coimbra, Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, Coimbra, Portugal.
European journal of clinical investigation
|September 23, 2024
概括
像血脑屏障 (BBB) 和血视网膜屏障 (BRB) 这样的神经血管接口在精神疾病中至关重要. 了解它们的变化为焦虑和抑郁等疾病提供了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 精神病学是一个精神病学.
背景情况:
- 血脑屏障 (BBB) 和血视网膜屏障 (BRB) 对于中枢神经系统 (CNS) 的恒温至关重要.
- 最初仅被视为保护性,这些神经血管接口现在被认为在中枢神经系统功能和功能障碍中的关键作用.
- 神经血管变化与各种大脑和眼睛疾病的早期阶段有关,并且越来越多地与精神疾病有关.
研究的目的:
- 审查目前关于精神疾病中BBB和BRB变化的证据.
- 专注于焦虑,严重抑郁症 (MDD),注意力缺陷/多动症 (ADHD) 和药物滥用 (甲基和可卡因).
- 检查神经炎症的作用,并确定与这些屏障变化相关的潜在生物标志物.
主要方法:
- 使用PubMed数据库进行了文献搜索.
- 综合了来自体外,动物和临床研究的证据.
- 该审查重点关注与特定精神疾病和药物滥用有关的BBB和BRB功能变化.
主要成果:
- 在各种神经精神疾病中发现了神经血管异常.
- 研究人员认为神经炎症是BBB和BRB变化的关键驱动因素.
- 报告了这些疾病的假定与障碍相关的生物标志物.
结论:
- 对BBB和BRB的功能有更深入的了解,对于神经精神疾病至关重要.
- 这些障碍物代表了精神疾病的潜在治疗点.
- 该综述弥合了神经精神疾病及其血管影响的当前知识之间的差距,突出了创新的管理方法.
关键词:
注意缺陷/多动症障碍注意力缺陷/多动症障碍血脑屏障 血脑屏障 血脑屏障 血脑屏障血液视网膜屏障 视网膜屏障滥用药物 滥用药物 滥用药物 滥用药物 滥用药物大型抑郁症主要是抑郁症.神经炎症是一种神经炎症.更多相关视频
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