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Updated: Jun 12, 2025

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
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一种聚马病毒酶活性模型,部分来源于SV40 T-抗原的AlphaFold2结构

Jong Shin1, Gretchen Meinke2, Alex A Bohm2

  • 1Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Journal of virology
|September 23, 2024
PubMed
概括

研究人员使用AlphaFold2来建模SV40 T-抗原酶,揭示了复制分叉时DNA解的关键特征. 这种结构性洞察力提出了一个"绳索爬行者"机制,这对于病毒DNA复制至关重要.

关键词:
在AlphaFold2中,我们将使用AlphaFold2.在DNA中,有DNA螺旋酶.在DNA解过程中,的T-抗原结构结构.希斯蒂丁的质子化原产地有约束力的领域.复制子复制子

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