干燥发酵香肠中的抗氧化和抗炎,这些香肠与Staphylococcus simulansQB7发酵
Hongying Li1,2,3, Linggao Liu2, Hongbing Fan4
1Guizhou Provincial Engineering Research Center of Ecological Food Innovation, School of Public Health, Guizhou Medical University, Guiyang 550025, China. hongyingli_718@163.com.
Food & function
|September 23, 2024
概括
葡萄球菌simulans QB7增强了发酵香肠中的抗氧化和抗炎. 计算分析确定了特定的和它们与关键蛋白质的相互作用,揭示了改善健康益处的机制.
科学领域:
- 食品科学 食品科学 食品科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 干发酵香肠是一种流行的食品.
- 人们越来越认识到发酵食品对健康的潜在益处.
- 识别增强有益化合物的微生物菌株是值得关注的.
研究的目的:
- 研究Staphylococcus simulans QB7对干发酵香肠中的抗氧化和抗炎的作用.
- 使用in silico方法阐明底层机制.
主要方法:
- 在基分析的序列.
- BIOPEP-UWM对抗氧化和抗炎活动的预测.
- 分子对接模拟用于预测与目标蛋白的相互作用 (Keap1, p65, IKK-β, JNK, p38).
主要成果:
- 葡萄球菌simulans QB7显著增加了的度和抗氧化和抗炎能力 (P <0.05).
- 确定了29个具有预测抗氧化和抗炎活性的序列.
- 分子对接揭示了GPGPWG和ANPILEAFG与参与炎症途径的关键蛋白质的特定结合相互作用.
结论:
- 葡萄球菌simulans QB7促进了干发酵香肠中的生物活性的生成.
- 鉴定的和它们预测的分子相互作用为抗氧化和抗炎作用的机制提供了洞察力.
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