在青少年和年轻成年人患有单边脑的群体基础上进行渐进的功能性高强度训练 - - 一种改善毛发动机功能,耐力和步行的工具. - 一个试点研究
Michèle Widmer1,2, Alice Minghetti3, Jacqueline Romkes2
1Neuroorthopaedic department, University Children's Hospital Basel, Basel, Switzerland.
Developmental neurorehabilitation
|September 23, 2024
概括
渐进功能高强度训练对于患有单边脑 (CP) 的青少年来说是安全的. 这项计划改善了毛细运动功能,这表明CP患者对日常活动和步行有潜在的益处.
科学领域:
- 康复医学 康复医学 康复医学
- 儿科物理治疗 儿科物理治疗
- 神经学 神经学
背景情况:
- 单侧脑 (CP) 影响运动功能,影响青少年的日常活动和生活质量.
- 目前单方面CP的康复策略往往侧重于个性化干预,不太重视以小组为基础的高强度功能培训.
研究的目的:
- 为了评估一个渐进的功能高强度训练计划的安全性和有效性,在一个小组设置中为青少年提供单边CP.
- 评估这项培训对日常功能指标的影响,包括总运动技能,行走耐力和步行参数.
主要方法:
- 一项试点研究涉及9名单边CP的青少年 (平均年龄16.9岁,GMFCS I-II级),他们完成了12周的培训 (每周2次).
- 综合评估包括3D步态分析,6分钟步行测试 (6MWT),临床检查和总运动功能测量-66 (GMFM-66).
主要成果:
- 该培训计划被发现是安全的,没有报告的不良事件.
- 在总运动功能测量-66 (GMFM-66) 评分 (p=.031, Δ=2.19%) 中观察到显著改善.
- 在6分钟步行测试 (6MWT) 性能 (p=.09) 和受影响的腿部推进率 (p=.067) 中,虽然在统计学上没有显著的改善趋势,但在6分钟步行测试 (6MWT) 性能 (p=.09) 和受影响的腿部推进率 (p=.067) 中,有所改善.
结论:
- 在小组环境中进行渐进性功能高强度训练似乎是一种安全且潜在的有效干预措施,用于增强单边CP的青少年的毛细运动功能.
- 研究结果表明,这种训练也可能有利于耐力和步态不对称,这需要进一步研究.
- 未来的研究应该包括上肢评估,并利用可穿戴惯性测量单元 (IMU) 来进行临床外运动分析,以提供更全面的评估.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Neuroplasticity
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.


