相关实验视频

Updated: Jun 12, 2025

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

血清N-终端Pro-B型天然尿素与中国人的胰岛素抵抗有关:丹阳研究

Ziwen Zheng¹, Junya Liang², Yun Gao²

¹Department of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.

Journal of clinical hypertension (Greenwich, Conn.)

|September 23, 2024

概括

较高的血清NT-proBNP水平与一般中国人群中胰岛素抵抗 (IR) 风险降低有关. 这项研究澄清了NT-proBNP和HOMA-IR之间的反向关联,表明它们具有保护作用.

科学领域:

心血管生物标志物心血管生物标志物
代谢健康代谢健康
流行病学流行病学

背景情况:

在一般人群中,N-终端血清B型亲尿素 (NT-proBNP) 与胰岛素抵抗 (IR) 之间的关系需要进一步研究.
胰岛素抵抗 (IR) 是心血管和代谢疾病的重要危险因素.

研究的目的:

为了研究血清NT-proBNP水平和IR之间的关联,通过HOMA-IR评估,在一个大型的社区中国人群中.
在不同的子组中描述NT-proBNP和IR之间的关系.

主要方法:

一项涉及丹阳市2945名参与者的横截面研究 (2017-2019).
血清NT-proBNP通过增强化学发光免疫试验测量.
IR是由HOMA-IR的最高性别特异四分位数定义的;分析使用NT-proBNP三分位数和lnNTproBNP.

主要成果:

在回归分析中,血清lnNTproBNP与HOMA-IR有显著的负相关性 (β = -0.19至 -0.25; p < 0.0001).
血清NT-proBNP的升高与较低的IR风险相关 (ORs:0.68和0.39分别为lnNTproBNP和顶部与底部三角动物;p < 0.0001).
在多个子组分析中观察到一致的反向关联.

结论:

血清NT-proBNP水平的增加与中国人群中胰岛素耐药性风险的降低密切相关.
这些发现表明NT-proBNP在抗胰岛素耐药性发展方面具有潜在的保护作用.

关键词:

这是一种N-终端的B型性性.对胰岛素耐药性的恒常模式评估胰岛素耐药性是一种胰岛素耐药性.

更多相关视频

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

Published on: June 25, 2018

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

相关概念视频

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Transducer Mechanism: Enzyme-Linked Receptors

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...