运动和瘤蛋白质组:来自神经母细胞瘤模型的见解
Abel Plaza-Florido1, Beatriz G Gálvez2,3, Juan A López4,5
1Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, California, United States.
Physiological genomics
|September 23, 2024
概括
在高风险神经母细胞瘤小鼠模型中,定期运动显著改变了瘤蛋白质组概况. 蛋白质和途径的这些变化表明,身体活动在儿童癌症中可能具有抗瘤效应.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 运动科学 运动科学
背景情况:
- 运动对儿科瘤生物学的影响在很大程度上仍未被探索.
- 高危神经母细胞瘤 (HR-NB) 是一种具有有限治疗选择的侵袭性儿童癌症.
研究的目的:
- 在HR-NB的小鼠模型中研究定期运动对瘤蛋白质组概况的影响.
- 在HR-NB瘤中识别运动调节的分子通路.
主要方法:
- 液体染色学与双重质谱学被用于分析瘤蛋白质组概况.
- 带有HR-NB的小鼠被随机分配到运动组 (5周的有氧和抵抗训练组合) 或对照组.
- 使用数据库和系统生物学三角形 (SBT) 算法进行了蛋白质-蛋白质相互作用网络和功能丰富分析.
主要成果:
- 与对照组相比,运动显著改变了HR-NB瘤中数百种蛋白质的丰度.
- 丰富的途径包括那些参与新陈代谢,氨基酸代谢,激素调节和信号通路的途径.
- SBT算法揭示了与能源生产,转录/翻译,亡和瘤抑制相关的功能类别的显著变化.
结论:
- 定期运动会在HR-NB的瘤蛋白质组中诱导实质性的分子变化.
- 这些变化,特别是能量代谢,亡和瘤抑制途径的变化,为运动在儿科癌症中的潜在抗瘤作用背后的分子机制提供了初步证据.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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