探索COVID-19中周期值和口腔表现之间的关系:全面的概述
Dalit Porat Ben Amy1, Hanan Rohana2, Maya Azrad2
1Unit of Oral Medicine, the Baruch Padeh "Tzafon" Medical Center, Poriya, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Acta odontologica Scandinavica
|September 23, 2024
概括
COVID-19患者经常经历口腔症状,如口腔干燥和口味变化. 较低的CT值,表明病毒载量较高,与严重疾病有关,并预测COVID-19的结果.
科学领域:
- 病毒学 病毒学
- 口腔医学是指口腔医学.
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 感染,或COVID-19,呈现出各种临床表现.
- 在COVID-19患者中有事报告口腔症状,但它们与病毒载荷的关联需要进一步调查.
研究的目的:
- 为了比较SARS-CoV-2-阳性与SARS-CoV-2-阴性个体的口腔表现.
- 调查口腔症状,病毒基因CT值和COVID-19预后之间的关系.
主要方法:
- 一项涉及353名怀疑COVID-19感染的成年患者的横截面研究.
- 通过RT-PCR证实了SARS-CoV-2携带,参与者填写了口腔和一般症状的问卷.
主要成果:
- 在SARS-CoV-2携带和口腔干燥,口味变化和不愉快的味道 (p < 0.001) 之间观察到显著的关联.
- 在具有较低E基因Ct值 (10-30) 的患者中,口腔水泡的发生频率更高.
- 恶口气,口腔干燥和味道变化等症状与E和N基因 (21-30) 的较低Ct值相关.
结论:
- 对于SARS-CoV-2 E和N基因的低Ct值意味着高病毒载量,并且与COVID-19的严重程度有关.
- 虽然口腔症状存在,但CT值和病毒载量是疾病预后的更关键指标.
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