在患有多发性骨髓瘤的患者中,对达拉图穆马布重复治疗的反应
Laura Souren1,2, Gabriele Ihorst2,3, Christine Greil1,2
1Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Center, University of Freiburg, Hugstetterstrasse 55, 79106, Freiburg, Germany.
Annals of hematology
|September 23, 2024
概括
对多发性骨髓瘤 (MM) 患者来说,Daratumumab重复治疗可能是有效的,特别是在交替药物组合和治疗暂停的情况下. 重新治疗是安全的,反应逐渐下降,并且观察到可比的无进展生存率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 达拉图穆马布是多发性骨髓瘤 (MM) 的关键治疗方法.
- 在MM患者中,达拉图穆马布再治疗的疗效和安全性需要进一步研究.
- 确定从再治疗中获益最多的患者子组是必不可少的.
研究的目的:
- 评估达拉图穆马布在多发性骨髓瘤 (MM) 重复治疗的有效性和安全性.
- 为了确定与成功的达拉图穆马布再治疗相关的患者特征.
- 评估治疗暂停和交替药物组合对再治疗结果的影响.
主要方法:
- 在2016年至2023年期间,293名MM患者接受达拉图穆马布治疗的回顾性分析.
- 在初始达拉图穆马布治疗和再治疗之间比较反应率,不良事件和生存率.
- 鉴定了22名接受达拉图穆马布再治疗的患者.
主要成果:
- 在8%的患者中,Daratumumab重复治疗是有效的,这些患者通常患有晚期疾病和先前治疗.
- 重新治疗的反应率为64% (第一),46% (第二) 和43% (第三),疗效逐渐下降.
- 无进展生存率在治疗线上是可比的,并且随着再治疗,不良事件并没有增加.
结论:
- 精心挑选的暴露于达拉图穆马布的MM患者可以通过重新治疗达拉图穆马布获得有益的反应.
- 交替使用抗髓瘤药物组合,初步良好反应和CD38抗体治疗暂停改善了再治疗结果.
- 用CD38抗体重新治疗是治疗多发性骨髓瘤的可行,有效和无毒的选择.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.4K
08:04In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
Published on: February 27, 2019
11.6K
相关概念视频
Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
