怀孕期间的流感感染以及后代发作风险
Yi-Feng Lee1, Yi-Hsuan Lin1,2,3, Ching-Heng Lin4
1Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.
JAMA network open
|September 23, 2024
概括
怀孕期间的母体流感感染与儿童发作,特别是发烧性发作的风险更高有关. 风险没有显著增加. 需要进一步的研究来了解神经发育机制.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 孕产妇和儿童的健康
背景情况:
- 发作是幼儿的一个常见的神经问题.
- 建议产前暴露于母体流感会增加儿童发作的风险.
研究的目的:
- 调查怀孕期间母亲流感感染与后代发作风险之间的关联.
- 为了区分各种发作类型的风险,包括和发烧性发作.
主要方法:
- 一项大型队列研究利用台湾的母婴健康数据库 (2004-2013).
- 确定了母子对,流感病例与对照病例的比率为1:4.
- 考克斯的比例危险回归模型被用来估计调整后的危险比率 (AHR).
主要成果:
- 分析了超过130万对母子对.
- 母体流感感染与9%的发作风险增加有关 (AHR,1.09;95% CI,1.05-1.14).
- 发烧风险增加了11% (AHR,1.11;95% CI,1.06-1.17)),但风险没有显著增加 (AHR,1.04;95% CI,0.97-1.13).
结论:
- 怀孕期间的母体流感与儿童发作风险增加有关,特别是发烧性发作.
- 该研究没有发现与的显著关联.
- 需要进一步的研究来探索影响神经发育的潜在机制.
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