叶酸摄入量和子宫内膜癌的风险:一个剂量反应元分析
Jiaye Long1, Du Wang1, Miyang Yang2
1Department of Interventional Radiology, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for The Nationalities, Yakeshi, Inner Mongolia, China.
Medicine
|September 23, 2024
概括
更高的叶酸摄入量可能会降低子宫内膜癌 (EC) 风险. 这次元分析发现了显著的线性趋势,表明叶酸消费对EC发病率的保护作用.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 预防医学 预防医学
背景情况:
- 叶酸消费与子宫内膜癌 (EC) 风险之间的联系尚不清楚.
- 现有的研究对这种关联提出了相互矛盾的发现.
研究的目的:
- 调查叶酸摄入量与EC风险之间的关系.
- 进行剂量反应元分析以量化关联.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane,Web of Science) 进行全面的文献搜索,截至2024年2月.
- 对15项研究 (9个病例控制,6个队列) 的元分析,涉及379570名参与者和8660个EC病例.
- 使用Stata 14进行的统计分析,遵循PRISMA指南和PROSPERO注册.
主要成果:
- 叶酸摄入量最高的类别显示,与摄入量最低的类别相比,EC风险降低了10% (RR=0.90,95% CI:0.78-1.05).
- 观察到一个统计学上显著的线性趋势 (P=0.231).
- 叶酸摄入量每增加50μg/天都与降低EC风险相关 (RR=0.974,95% CI:0.968-0.981).
结论:
- 叶酸摄入量显示出对子宫内膜癌的潜在保护作用.
- 研究结果表明,增加叶酸消费可能会降低EC的发病率.
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