一个带有芯片闭环调制的细胞混合系统
IEEE transactions on biomedical circuits and systems
|September 23, 2024
概括
研究人员开发了一种新的生物电子接口,使生物细胞和CMOS芯片之间的低延迟,闭环通信成为可能. 该系统为假肢和脑机界面的先进应用创造了人工信号通路.
科学领域:
- 生物电子接口 生物电子接口
- 神经科学是一个神经科学.
- 生物技术是生物技术.
背景情况:
- 生物细胞产生对生理功能至关重要的电信号.
- 目前的接口往往缺乏复杂的生物系统调制的速度和集成.
- 开发生物和电子系统之间的无集成是一个关键的挑战.
研究的目的:
- 为了创建一个生物电子接口,实时,电源细胞和混合信号CMOS集成电路之间的闭环通信.
- 为了证明这种接口在生物细胞之间创建人工信号通路的实用性.
- 探索在假肢和大脑机器接口等领域的应用.
主要方法:
- 采用了1024通道的CMOS电极阵列,用于同时记录和刺激生物细胞.
- 实现了芯片内闭环调制,内在延迟低于5μs.
- 开发了心肌细胞振荡器和神经元接口,以展示人工反通路.
主要成果:
- 成功建立了一个具有高密度记录和刺激能力的生物电子接口.
- 证明了人工信号通路的低延迟,芯片上的闭环调制.
- 创建了功能混合系统,包括可调节的心肌细胞振荡器和神经元抑制连接.
结论:
- 开发的细胞混合系统有效地模糊了生物和半导体系统之间的界限.
- 低延迟的闭环接口为生物细胞提供了新的人工反途径.
- 潜在的应用包括先进的假肢,脑机接口和基本生物学研究.
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