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相关概念视频

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Desensitization and Tachyphylaxis01:20

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
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Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

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Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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相关实验视频

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Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
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2017年北卡罗来纳州的STOP法案与阿片类药物分发的加速减少有关:全州分析,2013-2019年

Chris Gillette1,2, Amber K Brooks3, Gayle B Bodner1,3

  • 1Department of PA Studies, School of Medicine, Wake Forest University.

North Carolina medical journal
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PubMed
概括
此摘要是机器生成的。

北卡罗来纳州的STOP法案与减少阿片类药物处方和日数相关.

关键词:
克里斯·吉莱特克里斯·吉莱特美国医疗保险 (Medicare) 的医疗保险."停止行动法案" (STOP Act) 是一个法律.唤醒森林是一个森林.麻醉学 麻醉学北卡罗来纳州的北卡罗来纳州.在阿片类药物阿片类药物.药房 药房 药房 药房

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科学领域:

  • 公共卫生 公共卫生
  • 药物经济学 药物经济学
  • 卫生政策研究 卫生政策研究

背景情况:

  • 阿片类药物处方模式及其对公共卫生结果的影响.
  • 立法干预在控制阿片类药物使用中的作用.
  • 医疗保险D部分受益人作为研究处方药趋势的关键人群.

研究的目的:

  • 量化北卡罗来纳州STOP法案之前和之后的阿片类药物发行和供应日的变化.
  • 评估NC STOP法案对助理医生和执业护士处方的影响.
  • 评估NC STOP Act与减少阿片类药物处方日供应之间的关联.

主要方法:

  • 医疗保险D部分公共用途档案 (2013-2019) 的二次分析.
  • 包括北卡罗来纳州的提供者,选择日程表II (CII),III (CIII) 药物,以及特拉马多尔 (CV).
  • 使用多变量波桑回归模型进行数据分析.

主要成果:

  • 包括阿片类药物的受人口调整后索赔数量从2013年的180,565.2/100,000下降到2019年的79,329.12/100,000.
  • 多变量模型表明,对于CII,CIII和tramadol,每个提供商的索赔和NC STOP Act后的供应日减少.
  • 在研究期间观察到的CII,CIII和特拉马多尔的处方总体下降.

结论:

  • 自2013年以来,在医疗保险受益者中观察到阿片类药物处方的下降趋势.
  • 在NC STOP法案实施后,阿片类药物使用的这种趋势加速了.
  • 该研究强调了立法措施对阿片类药物处方行为的潜在影响.