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用脂质体阻断MPS控制纳米颗粒的药理动力学,以大小依赖的方式

Iaroslav B Belyaev¹, Aziz B Mirkasymov^1,2, Vladislav I Rodionov^1,3

¹Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.

Biomedical materials (Bristol, England)

|September 23, 2024

概括

通过更大的脂质体阻断单核细胞系统 (MPS),可以改善纳米医药的循环. 这项研究表明,增加脂质体大小可以增强MPS阻塞,提高癌症治疗药物递送潜力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

纳米医药的药理动力学可以通过暂时阻断单核细胞系统 (MPS) 来增强.
脂质体是有效的MPS阻断剂,但它们的效率取决于尺寸等属性.
了解脂质体大小效应对于优化纳米药物输送至关重要.

研究的目的:

为了研究阻断脂质体大小如何影响单核细胞系统 (MPS) 阻断效率.
为了评估脂质体大小对纳米药物药理动学的影响,在体外和体内.
为了确定最佳的脂质体大小,以增强药物输送和癌症治疗.

主要方法:

使用RAW 264.7巨细胞进行体外研究,以评估脂质体吸收和度.
在小鼠体内研究以评估阻断脂质体对磁性纳米粒子循环的影响.
在MPS阻塞后,分析纳米粒子在肝脏,脏和肺部的分布.

主要成果:

脂质体大于200nm的和巨细胞在体外吸收.
所有测试的脂质体大小都减少了小鼠的肝脏吸收和延长了磁性纳米粒子的循环.
脂肪体大小的增加导致了更明显的MPS阻塞效应和改变的纳米粒子生物分布.

结论:

脂质体大小是调节MPS阻塞效率的关键因素.
较大的阻断性脂质体增加了纳米药物循环时间,改变了生物分布.
优化阻断脂质体大小为改善基于纳米医学的药物输送和癌症治疗提供了一个有希望的策略.

关键词:

在MPS的封锁中,MPS的封锁.脂质体是一种脂质体.单核细胞系统的单核细胞系统.纳米颗粒的交付方式药物动力学药物动力学

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