一种天然的小分子皮诺布林通过GPR120-ERK1/2通路抵抗高脂肪饮食引起的肥胖症
Ziyi Zhang1, Zhaozhao He1, Xinyi Wang1
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
The Journal of nutritional biochemistry
|September 23, 2024
概括
皮诺森布林 (PB) 是一种天然的黄类化合物,有效地减少肥胖小鼠的体重增加和胰岛素抵抗,没有副作用. 这种天然化合物向G蛋白结合受体120 (GPR120) 和细胞外调节激酶1/2 (ERK1/2) 途径,用于治疗肥胖症.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
- 自然产品 自然产品
背景情况:
- 肥胖是一个重要的全球健康问题,战略重点是白色脂肪组织动员和减少脂肪合成.
- 自然化合物为肥胖等代谢障碍提供了潜在的治疗途径.
研究的目的:
- 通过连接地图 (CMap) 方法识别具有抗肥胖潜力的天然化合物.
- 调查皮诺布林 (PB) 在改善肥胖和相关代谢功能障碍方面的疗效和机制.
主要方法:
- 使用高脂肪饮食 (HFD) 诱导的肥胖小鼠接受PB治疗的体内研究.
- 在体外实验中评估PB对前脂肪细胞脂肪生成和脂质生成的影响.
- 分子对接,细胞热转移试验 (CETSA) 和西式涂抹,以阐明涉及G蛋白结合受体120 (GPR120) 和细胞外调节激酶1/2 (ERK1/2) 的分子机制.
主要成果:
- 在HFD养的小鼠中,PB补充剂显著降低了体重增加和改善了胰岛素抵抗.
- PB治疗抑制了白色脂肪组织的扩张,降低了脂质生成和增加了脂解基因表达.
- PB直接与GPR120结合,激活下游的ERK1/2通路,从而抑制脂肪原分化.
结论:
- 皮诺坎布林通过GPR120-ERK1/2信号通路调节脂解和脂生成,显示出显著的抗肥胖作用.
- PB是一种有前途的天然治疗剂,用于治疗肥胖症,没有观察到对肝脏和脏功能的不良影响.
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