突变TP53循环瘤DNA的动态变化预测了患有高度卵巢癌的患者的结果
Maria Kfoury1,2, Clément Bonnet3, Nicolas Delanoy4
1Medical Oncology Department, Institut Gustave-Roussy, Villejuif, Île-de-France, France kfourym@ipc.unicancer.fr.
概括
在循环瘤DNA (ctDNA) 中监测TP53突变可以预测高度卵巢癌的结果. 化疗或手术后ctDNA水平上升表明存活率较差,指导辅助治疗决策.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 遗传学 是一个遗传学.
背景情况:
- 高度卵巢癌缺乏可靠的生物标志物来预测治疗反应.
- TP53突变在卵巢癌中很常见,但它们作为动态生物标志物的实用性尚未得到充分研究.
研究的目的:
- 研究监测循环瘤DNA (ctDNA) 中TP53突变的潜力,作为高度卵巢癌的预测生物标志物.
- 为了将ctDNA TP53突变动态与治疗反应和患者存活率相关联.
主要方法:
- 前性研究 (NCT03010124) 涉及对卵巢癌患者进行生物样本的顺序采集.
- 使用下一代测序对TP53突变的ctDNA分析.
- 将ctDNA TP53突变与瘤组织进行比较,并评估不确定潜力的克隆性血液形成 (CHIP).
主要成果:
- 诊断时在所有患者中检测到ctDNA,ctDNA和瘤组织之间TP53突变的一致性为77%.
- 在新辅助化疗期间增加ctDNA水平与未能实现完整的细胞还原手术相关 (60%的患者).
- 在ctDNA中增加或de novoTP53突变趋向于更差的无进展生存期 (10个月与26.5个月相比). 手术后检测到的ctDNA与较差的生存率有关.
结论:
- 在ctDNA中监测TP53突变可以作为高级卵巢癌中可靠的瘤特异性生物标志物.
- 治疗期间和之后的ctDNA动态可以预测治疗失败和患者的存活率.
- 在ctDNA中监测TP53突变可能为卵巢癌患者指导最佳辅助疗法选择.
关键词:
卵巢癌 卵巢癌 卵巢癌
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