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Updated: Jun 12, 2025

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人类和老鼠ABCC4/Abcc4对代谢物的不同选择性

Brayden D Whitlock1, Yingze Ma1, Gwenaëlle Conseil1

  • 1Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen's University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (Y.W., J.D.S.).

Drug metabolism and disposition: the biological fate of chemicals
|September 23, 2024
PubMed
概括

鼠标Abcc4 (mABCC4) 不像人类同类 (hABCC4) 不能携带物种. 传送器功能的这种差异可能解释了为什么在动物中与人类相比具有较差的致癌性.

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