胆酸作为养信号,功能性食物模仿胆酸功能的胆酸
1Nutri-Life Science Laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Bioscience, biotechnology, and biochemistry
|September 23, 2024
概括
胆酸受体TGR5 (TGR5) 的激活会增加骨肌肉质量. 特定的食物化合物,如诺米林,也通过激活TGR5促进肌肉生长,提供潜在的治疗策略.
科学领域:
- 生物化学 生化学
- 身体生理学 身体生理学
- 分子生物学分子生物学
背景情况:
- 胆酸结合受体TGR5 (TGR5) 在各种生理过程中发挥作用.
- 它在骨肌中的特定功能,特别是关于肌肉质量调节的功能,仍然不完全理解.
研究的目的:
- 研究TGR5在骨肌肉质量调节中的作用.
- 为了确定激活TGR5并影响肌肉质量的天然化合物.
主要方法:
- 在骨肌中表达人类TGR5的转基因小鼠的发展.
- 对TGR5转基因和TGR5缺乏的小鼠肌肉质量变化的分析.
- 对TGR5基因表达的研究,以应对运动和内质网膜 (ER) 压力.
- 使用开发的评分系统,对食品成分的TGR5激动剂活性进行选.
- 细胞培养和体内实验验验证已识别的化合物的作用.
主要成果:
- 过度表达TGR5的转基因小鼠表现出增加的骨肌肉质量.
- 缺少TGR5的小鼠显示肌肉质量下降.
- 运动后TGR5基因表达升级,与ER压力有关.
- 类类类分子诺米林和其他三类化合物被确定为TGR5激动剂.
- 这些化合物促进了蛋白质合成和增加肌肉质量 in vitro 和 in vivo.
结论:
- TGR5激活是骨肌肉质量的关键调节者.
- 运动和食后胆酸升高刺激了骨肌肉中的TGR5.
- 像诺米林这样的食化合物可以通过TGR5激动性增强肌肉质量.
- TGR5激动剂代表了肌肉相关疾病的潜在治疗途径.
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