使用电子健康记录链接的药房分发数据评估青少年异常性关节炎中甲甲酸坚持的评估
Dori Abel1, David Anderson1, Michael J Kallan2
1The Children's Hospital of Philadelphia and The Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Arthritis care & research
|September 23, 2024
概括
通过将药房和电子健康记录联系起来,确定了影响青少年异常性关节炎 (JIA) 甲状腺素坚持的因素. 更好的遵守与改善的疾病活动有关,突出显示了有针对性的干预措施的需要.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 医疗信息学 医疗信息学
背景情况:
- 青春期异常性关节炎 (JIA) 需要慢性药物管理,通常是用甲状腺素 (MTX).
- 评估药物坚持对于治疗有效性至关重要,但可能具有挑战性.
- 电子健康记录 (EHR) 和药房数据为客观的遵守测量提供了潜力.
研究的目的:
- 为了确定与JIA患者的MTX坚持相关的特征.
- 为了确定MTX坚持和JIA疾病活动之间的关系.
主要方法:
- 一项对224名JIA患者进行的回顾性队列研究,这些患者在2016年至2023年期间开始MTX.
- 使用药物持有比率 (MPR) 来估计药房配药数据与EHR相关的遵守率.
- 统计分析包括双变量比较和多变量线性回归.
主要成果:
- 36.2%的患者被归类为不坚持 (MPR <80%).
- 年龄较小,黑人种族和儿童机会指数较低与不遵守相关.
- 与非坚持患者相比,坚持患者在12个月后的活跃关节数量在统计学上显著地减少.
结论:
- 连接药房和电子健康记录数据提供了一个客观的方法来评估慢性药物坚持.
- 人口和地区层面的因素影响MTX在JIA的坚持.
- 坚持与改善的JIA疾病活动有关,这表明可能对社会弱势群体进行干预.
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