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Updated: Jun 12, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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对CXCR4调制和寡合化的结构见解

Kei Saotome1, Luke L McGoldrick2, Jo-Hao Ho3

  • 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. kei.saotome@regeneron.com.

Nature structural & molecular biology
|September 23, 2024
PubMed
概括

通过CXCL12激活化基因受体CXCR4的方法详细使用了冷EM. 结构显示了对手AMD3100和抗体REGN7663的结合,以及影响CXCR4寡合化的功能.

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Characterization of Multi-subunit Protein Complexes of Human MxA Using Non-denaturing Polyacrylamide Gel-electrophoresis08:55

Characterization of Multi-subunit Protein Complexes of Human MxA Using Non-denaturing Polyacrylamide Gel-electrophoresis

Published on: October 28, 2016

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