预后营养指数和子宫内膜癌患者的存活率:一个元分析
Li Zhang1, Fengliang Wang2, Cong Wan3
1Department of Gynaecology and obstetrics, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing, 100038, China.
Reproductive sciences (Thousand Oaks, Calif.)
|September 23, 2024
概括
预后营养指数 (PNI) 是子宫内膜癌 (EC) 存活率的重要预测指标. 低PNI水平与EC患者的整体存活率和无进展存活率较差有关.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 生物统计学 生物统计学
背景情况:
- 预后营养指数 (PNI) 是癌症结局的潜在生物标志物.
- 目前缺乏对PNI在子宫内膜癌 (EC) 存活率中的作用的定量分析.
研究的目的:
- 通过元分析评估PNI对EC患者的整体生存期 (OS) 和无进展生存期 (PFS) 的预后价值.
主要方法:
- 在多个数据库 (PubMed,EMBASE,Web of Science,Wanfang,CNKI) 中进行了全面的文献搜索.
- 包括在内的是队列研究,提供了基于PNI的OS和PFS危险比率 (HR) 的数据.
- 使用随机效应模型计算了具有95%置信区间 (CI) 的聚合HR.
主要成果:
- 分析包括10项研究,涉及3656名患者.
- 在EC患者中,低PNI与较差的OS (HR=2.01) 和PFS (HR=2.75) 有显著的关联.
- 亚组分析证实了PNI在各种研究特征上的预后影响的一致性.
结论:
- 预后营养指数 (PNI) 作为一种有价值的预后标志物,用于诊断患有子宫内膜癌的患者的生存.
- 在不同患者群体和研究方法中,PNI的预测能力强大.
相关概念视频
Cancer Survival Analysis
331
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
331
Kaplan-Meier Approach
107
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
107
Comparing the Survival Analysis of Two or More Groups
158
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
158


