皮囊性甲状腺癌患者的生存率的动态估计:一个回顾性队列研究
Xiaoyu Ji1, Ruonan Yu1, Wei Sun1
1Department of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
Endocrine
|September 23, 2024
概括
卵泡性甲状腺癌 (FTC) 的动态生存率随着时间的推移而有所改善,特别是在患有远程转移的患者中. 这项研究强调了动态生存分析对于更精确的FTC预后的价值.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 有限的研究存在于皮囊性甲状腺癌 (FTC) 的动态生存率.
- 了解时间生存变化对于患者的管理和预后至关重要.
研究的目的:
- 在患有卵泡性甲状腺癌 (FTC) 的患者中,分析随着时间的推移而发生的活力生存概率变化.
- 通过使用动态生存估计提供更精确的生存预测.
主要方法:
- 从SEER数据库中对10,617名FTC患者 (2000-2019) 的回顾性分析.
- 卡普兰-梅尔方法用于疾病特异性生存期 (DSS) 估计.
- 风险函数用于年度死亡风险和生命表方法用于条件生存 (CS) 计算.
主要成果:
- 总体而言,5年DSS为96.6%,而10年DSS为94.6%.
- 在不同SEER阶段观察到DSS的显著差异 (P < 0.001).
- 随着时间的推移,死亡风险下降,2.5年达到顶峰;CS显示出上升趋势,特别是在远程转移病例中.
结论:
- 对于FTC患者的预后有动态的改善,并且取决于阶段.
- 在患有远程转移的患者中,发现了最显著的生存改善.
- 动态生存分析 (死亡危险,CS) 为FTC提供比传统方法更精确的预测.
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