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Updated: Jun 12, 2025

Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA
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Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA

Published on: November 9, 2019

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一种具有降低细胞毒性和通过巨基突变增强蛋白质表达的新型自我放大mRNA

Yue Gong1, Danni Yong1, Gensheng Liu1

  • 1Shanghai Virogin Biotech Co. Ltd, Jiading District, Shanghai, 200000, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 24, 2024
PubMed
概括

自放大mRNA (saRNA) 非结构蛋白的突变减少了复制和先天免疫反应. 这增强了有效载荷表达并降低了细胞毒性,优化了saRNA用于治疗应用.

关键词:
天生的免疫反应.蛋白质表达 蛋白质表达自强化的RNA.

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