非编码RNA的多中介调制:高血压治疗的新疗法 - - 综述
Ilgiz Gareev1, Ozal Beylerli2, Tatiana Ilyasova3
1Central Research Laboratory, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin Street, 450008, Russia.
Current hypertension reviews
|September 24, 2024
概括
聚可能通过调节非编码RNAs (ncRNAs) 来提供一种新的高血压管理方法. 这些天然化合物显示出向心血管疾病相关途径的潜力,提供了一条新的治疗途径.
科学领域:
- 分子生物学分子生物学
- 心血管研究研究心血管研究
- 营养科学 营养科学
背景情况:
- 高血压 (HTN) 是心血管疾病 (CVD) 的首要危险因素,对全球死亡率作出重大贡献.
- 目前对HTN的药理治疗有局限性,包括副作用和不完全的病理覆盖.
- 非编码RNAs (ncRNAs),如microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),正在成为HTN病变发生的关键调节者.
研究的目的:
- 审查多在调节高血压管理中的ncRNA表达和功能的潜力.
- 在HTN的背景下,探索聚醇影响ncRNA介导途径的机制.
- 讨论针对心血管健康中的ncRNAs的多基疗法的挑战和未来方向.
主要方法:
- 文献综述综合了体外和体内研究的证据.
- 分析聚化合物,如EGCG,白醇,黄素和青素.
- 专注于高血压相关的细胞过程中的ncRNA调节,包括氧化应激,内皮功能和血管重塑.
主要成果:
- 聚醇显示出调节ncRNA表达和功能的能力.
- 特定的多影响了参与减少氧化应激,增强内皮功能和减轻HTN血管改造的途径.
- 有证据表明,多通过ncRNA介导的机制产生治疗作用.
结论:
- 聚醇通过向ncRNAs,代表了对高血压的有希望的治疗策略.
- 需要进一步的研究,包括临床试验,以确定基于多的干预措施的疗效和优化应用.
- 用聚醇准ncRNA可以提供一种新的方法来管理高血压和其他心血管疾病.
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