优化Glyburide装载的纳米悬浮通过球磨和均质化技术:一个中央复合材料设计方法提高可溶性
Damla Gungor1, Eren Aytekin1, Yagmur Akdag1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey.
Current pharmaceutical design
|September 24, 2024
概括
用球磨和均质化开发了甘化纳米悬浮剂,几乎使溶解度增加了一倍,并增强了溶解. 这种方法改善了吸收和生物可用性差的配方.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 格利布里德是一种BCSII类药物,具有较低的溶解性和透性,阻碍了其治疗疗效.
- 草甘的潜在应用范围延伸到阿尔茨海默氏症治疗.
- 开发先进的配方是提高甘化物生物可用性的关键.
研究的目的:
- 制备甘化物纳米悬浮剂,以提高溶解性和溶解率.
- 使用中央复合材料设计优化纳米悬浮配方.
- 研究球磨和均质化对甘化物物理化学性质的影响.
主要方法:
- 甘化物纳米悬浮是使用结合球磨和均化技术制备的.
- 使用中央复合材料设计进行了配方优化,使用各种参数,如磨时间,均化周期和Pluronic F-127/glyburide比率.
- 物理化学表征包括粒子大小分析,泽塔潜力,可溶性研究,X射线衍射 (XRD),扫描电子显微镜 (SEM),微分扫描热度计 (DSC) 和里埃变换红外光谱 (FT-IR).
主要成果:
- 甘化物纳米悬浮实现了244.6±2.685nm的颗粒大小.
- 甘化的和溶解度在纳米晶体形成后几乎翻了一番.
- 描述证实了成功的纳米晶体形成,没有药物辅助剂不相容性,并保持了药物的稳定性.
结论:
- 球磨和同质化有效提高了甘化的溶解度和体外释放.
- 开发的纳米悬浮配方有望改善吸收不良药物的生物可用性.
- 这种方法提供了一个可行的策略,以提高具有挑战性的药物化合物的输送.
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