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通过休息状态功能性MRI评估的急性甲状腺毒性肌肉病的异常脑区域活动

Yaqi Kuang¹, Xinghuan Liang¹, Wei Ye²

¹Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, PR China.

Acta radiologica (Stockholm, Sweden : 1987)

|September 24, 2024

概括

休息状态的fMRI揭示了急性甲状腺毒性肌肉病 (ATM) 患者的大脑活动的改变,特别是在上额 (SFG) 中. 这些发现提高了我们对ATM的理解.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
内分泌学在内分泌学.

背景情况:

在急性甲状腺毒性肌肉病 (ATM) 中,腹筋的神经生理基础仍然不清楚.
识别受影响的大脑区域对于理解ATM病理生理学至关重要.

研究的目的:

用静止状态功能磁共振成像 (rs-fMRI) 来研究ATM患者的区域大脑活动.
评估大脑活动的变化及其与临床标志物的相关性.

主要方法:

rs-fMRI对16名ATM患者,16名甲状腺功能高患者和16名健康对照进行.
分析包括低频波动的分数幅度 (fALFF),区域同质性 (ReHo) 和功能连接性 (FC).

主要成果:

与对照组和甲状腺功能高的患者相比,ATM患者在前额和运动区域表现出改变的ReHo和FC.
在ATM患者的右上额头 (SFG) 中观察到减少的fALFF和ReHo.
功能性大脑活动与甲状腺激素水平和抗体正相关.

结论:

rs-fMRI的发现表明,在ATM中,特定大脑区域 (尤其是SFG) 的功能活动异常.
这项研究提供了关于ATM的神经生理学基础的见解.

关键词:

急性甲状腺毒性肌肉病变症是什么巴麻 (Bulbar Paralysis) 是一种导致骨头的疾病.额头回形 (Frontal Gyrus) 是一个前额回形.在中心前的Gyrus.静止状态的功能磁共振成像技术

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