基于不同受体调制的含有索的NIR发射光敏剂的光疗应用
Shuge Chen1,2, Jianqing Li3, Weidong Yin2
1Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, Jieyang, P. R. China. smji@gdut.edu.cn.
Journal of materials chemistry. B
|September 24, 2024
概括
新的酸盐为癌症治疗提供了改进的光动力学疗法 (PDT) 和光热疗法 (PTT). 这些化合物克服了传统光敏感剂的局限性,在临床前模型中显示了降低的毒性和增强的疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 有机化学 有机化学
背景情况:
- 光动力疗法 (PDT) 对癌症和传染病治疗至关重要,但由于瘤缺氧和深度透而面临挑战.
- 传统的光敏感剂 (PSs) 在低氧环境中经常产生有限的活性氧物种 (ROS),并可能表现出暗毒性.
- 将PDT与光热疗法 (PTT) 结合起来可以改善抗瘤效果,但需要优化治疗剂.
研究的目的:
- 设计和合成基于烯的新型光敏感剂,以提高PDT和PTT的协同作用.
- 解决盐的局限性,包括黑暗中毒性和低氧条件下性能差.
- 开发具有改善ROS生成和光热转换效率 (PCE) 的近红外 (NIR) 发射剂.
主要方法:
- 分子设计涉及烯核心,烯合并,并结合结构调.
- 合成四种发射NIR的聚合诱导排放化盐.
- 评估暗毒性,ROS生成,线粒体向,光热转换效率 (PCE) 和体外抗瘤功效.
主要成果:
- 合成的烯盐与烯类似物相比,显著降低了暗毒性.
- 加入二使得I型和II型ROS产生协同作用.
- 优化了DA结构和振动模式,将激发转移到NIR区域,并改善了PCE (FCN-TPAQ-BP的高达39.2%).
- FCN-TPAQ-BP表现出优异的ROS生成,线粒体向,良好的生物相容性和低暗毒性.
结论:
- 开发的基于的策略为协同作用的PDT/PTT剂提供了有前途的分子设计.
- 合成的NIR发射的化盐显示出克服缺氧瘤微环境的潜力.
- FCN-TPAQ-BP是提高PDT在癌症治疗中的疗效的强有力的候选者,因为它具有平衡的治疗性质.
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