脆弱和痛苦的恶性循环:一个双面的因果关系揭示了
Ruipeng Zhong1, Yijian Chen1, Lanhua Zhong1
1Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, China.
Frontiers in medicine
|September 24, 2024
概括
这项研究表明,老年人疼痛和虚弱之间存在双向因果关系. 管理疼痛可能有助于预防脆弱性,这表明疼痛评估对于脆弱性评估至关重要.
科学领域:
- 老年学是指老年学的学科.
- 疼痛医学 医学 疼痛医学
- 遗传流行病学遗传流行病学
背景情况:
- 衰老的生理衰退通常与疼痛和虚弱有关.
- 脆弱和疼痛之间的因果关系需要进一步调查.
研究的目的:
- 通过两样本的门德尔随机化 (MR) 方法调查虚弱和疼痛之间的潜在因果关系.
- 检查虚弱和疼痛之间的双向关系,包括特定部位的疼痛.
主要方法:
- 利用两样双向门德尔随机化 (MR) 与来自欧洲祖先种群的全基因组关联研究总结数据.
- 分析了脆弱性 (脆弱性指数和表型) 和疼痛,包括关节,四肢,胸脊和腰部疼痛.
- 采用逆方差加权来估计因果关系,并进行敏感性分析.
主要成果:
- 对脆弱性的遗传倾向与疼痛风险增加显著相关 (脆弱性表型OR:1.73;脆弱性指数OR:1.36).
- 对疼痛的遗传倾向与较高的脆弱风险有关.
- 虚弱表型与关节,四肢和腰部疼痛的风险增加有关;四肢和腰部疼痛增加了虚弱风险.
结论:
- 这项研究提供了证据,证明虚弱和疼痛之间存在双向因果关系.
- 解决疼痛对于预防虚弱是很重要的.
- 建议将疼痛评估纳入脆弱性评估系统.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.6K
09:00Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
Published on: July 7, 2023
3.4K
相关概念视频
Fatigue
174
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
174
Models of Health Promotion and Illness Prevention II
1.6K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
The agent-host-environment model states that disease results...
1.6K
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
Depressive Disorders: Etiology
56
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
56
Flail Chest-I
152
Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
152
Classification of Illness
7.4K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.4K
