相关实验视频
Updated: Jun 12, 2025

05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
1.5K
用于止痛药片剂量形式配方的2 - - - - - - 4 - - 甲基 - - 甲基 - - 甲基 - - 氧基 - - 酸的表征
Wuryanto Hadinugroho1, Yudy Tjahjono1, Kuncoro Foe1
1Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Surabaya, 60112, Indonesia.
Current research in pharmacology and drug discovery
|September 24, 2024
概括
这项研究优化了4CH2Cl片的配方,以实现潜在的止痛作用. 使用简单格子设计确定了最佳药片成分,显示出有希望的止痛活性.
科学领域:
- 制药科学 制药科学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化合物2 - - - - - - - - - 甲基氧酸 (4CH2Cl) 是一种来自酸的潜在止痛剂.
- 将4CH2Cl的表征和配制成药片剂型对其发展至关重要.
研究的目的:
- 为了研究粉糖酸盐 (SSG) 和聚烯利 K-30 (PVP-K30) 单独或组合对4CH2Cl片的配方的影响.
- 为了确定4CH2Cl的最佳平板组合,使用双因素简单格子设计.
主要方法:
- 采用了双因素简单格子设计和直接压缩方法来制药片.
- 评估了SSG和PVP-K30对平板电脑性能的影响,包括卡尔指数,豪斯纳比,硬度,易碎性,分解时间和药物释放.
- 使用热板方法评估优化的4CH2Cl片的止痛活性.
主要成果:
- 无论是SSG还是PVP-K30,都会增加药片的硬度,易碎性,分解时间和药物释放,同时也会影响卡尔指数和豪斯纳比率.
- SSG和PVP-K30的组合显示出类似的效果,特别是减少了分解时间.
- 确定了一种最佳的药片配方,含有4CHCl (300毫克),Ne (75毫克),SSG (33.60毫克),PVP-K30 (22.40毫克),MCC (40毫克) 和SDL (高达800毫克).
结论:
- 优化的4CH2Cl药片配方表现出作为一种新型止痛药的潜在用途的有利特征.
- 该研究通过系统的配方开发和评估成功确定了最佳的药片成分.
相关概念视频
Factors Influencing Drug Absorption: Pharmaceutical Parameters
123
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
123
Analgesia and Pain Management
551
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
551
Factors Influencing Drug Absorption: Physicochemical Parameters
238
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
238
Spasmolytic Agents: Chemical Classification
870
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
870
Local Anesthetics: Chemistry and Structure-Activity Relationship
4.3K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
4.3K
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
2.6K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
2.6K

