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功能隔离和性降低与精神分裂症的症状严重性和认知障碍有关:一项大型研究
Haohao Yan1, Yiding Han1, Xijia Xu2
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
精神分裂症患者表现出大脑网络拓的改变,功能分离减少,但保持了整合. 这些拓变化与症状和认知缺陷相关,证实了精神分裂症中的网络功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 以前对精神分裂症患者功能连接体 (TP-FC) 的拓性质的研究,由于样本规模小,数据处理多样,结果不一致.
- 这些不一致性凸显了对精神分裂症中大脑网络变化的大规模标准化研究的需要.
研究的目的:
- 通过使用统一的数据处理,在大量SZP队列中调查异常TP-FC.
- 探索TP-FCs与SZPs (A-TP-SCs) 中的临床症状或认知功能之间的关联.
主要方法:
- 这是一项大规模的研究,涉及6个数据集中的497名SZP和374名健康对照 (HC).
- 使用ComBat.Bat进行统一的成像数据预处理,功能连接矩阵配置和数据协调.
- 计算各种拓性质 (TPs) 以评估大脑功能整合 (FI) 和功能分离 (FS),然后对A-TP-SCs进行部分相关性分析.
主要成果:
- 与HC相比,SZP表现出全球功能分离 (FS) 和弹性受损,但与HC相比,SZP保持了小世界和全球功能整合 (FI).
- 在感官区域观察到节点FI和FS的下降,而在认知和信息整合区域则观察到节点FI的增加.
- 在TP-FC和正/负症状,以及诸如处理速度和抑制控制等认知功能之间发现了显著的关联.
结论:
- 减少FS和弹性,以及确定了A-TP-SCs,证实了精神分裂症的病理障碍.
- A-TP-SCs和TP-FCs之间的高内部一致性强烈支持这些关于精神分裂症功能连接体属性的发现.
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