对情境恐惧表达的性别差异与中部前额叶皮层活动的改变有关
Katherine Vazquez1, Ryan G Parsons1
1Stony Brook University, Department of Psychology, 100 Nicolls Rd., Stony Brook, NY, 11794.
bioRxiv : the preprint server for biology
|September 24, 2024
概括
性差异存在于情境恐惧表达中. 男人表现出更多的结行为,而前临界和下临界皮层的神经活动在两性之间有所不同,这影响了创伤后应激障碍研究.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 比较心理学比较心理学
背景情况:
- 了解恐惧表达的神经基础对于研究诸如创伤后应激障碍 (PTSD) 等病态恐惧反应至关重要.
- 创伤后应激障碍在女性中更为普遍,但雌性动物在表达恐惧时的神经回路相互作用仍未得到充分研究.
- 研究恐惧电路中的性别差异可以提供有关PTSD病理生理学的见解.
研究的目的:
- 为了确定神经活动是否在雄性和雌性大鼠之间不同,在特定的中间前额叶皮层 (mPFC) 在情境恐惧表达期间的投影.
- 为了检查mPFC神经元中的神经活动,不投射到腹侧周水管灰色 (vlPAG) 性别之间.
- 阐明性在恐惧电路激活中的作用.
主要方法:
- 在雄性和雌性大鼠的vlPAG中注入病毒逆行追踪器.
- 训练老鼠在情境恐惧条件化任务中,然后再暴露于情境.
- 在特定的mPFC区域 (vlPAG投射和非投射神经元) 使用EGR1免疫光测量神经活动.
主要成果:
- 在情境恐惧测试中,男性表现出明显高于女性的结行为.
- 在vlPAG投射神经元中,与对照组相比,男性在训练和测试后表达EGR1的增加;女性没有显著变化.
- 在非vlPAG发射神经元中,男性在前极皮质中具有更高的恐惧诱导EGR1,而女性在下极皮质中显示出更高的EGR1.
结论:
- 对情境恐惧表达的性别差异与中部前额叶皮层中独特的神经活动模式有关.
- 前肢和下肢皮层在性别之间表现出差异性的激活,这表明它们参与了性别特异的恐惧反应.
- 这些发现有助于理解恐惧和PTSD中性别差异的神经基础.
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