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电磁波破坏了SARS-CoV-2尖端蛋白的稳定,并降低了SARS-CoV-2病毒样粒子 (SC2-VLP) 的感染力

Skyler Granatir¹, Francisco M Acosta², Christina Pantoja²

¹Epirus Inc., Torrance, California, USA.

bioRxiv : the preprint server for biology

|September 24, 2024

概括

电磁波可以使严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 失活. 2.5-3.5 GHz之间的特定频率降低了病毒感染力和附着在宿主细胞中的能力.

科学领域:

病毒学病毒学
电磁学电磁学电磁学电磁学
公共卫生公共卫生

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 传播仍然是一个全球卫生问题.
电磁波为禁用SARS-CoV-2等病毒提供了一个潜在的策略.
电磁波在减少SARS-CoV-2传染性的有效性需要进一步调查.

研究的目的:

确定能够中和SARS-CoV-2病毒样粒子 (SC2-VLPs) 的特定电磁波频率.
研究电磁波对SARS-CoV-2感染性和病毒附着机制的影响.

主要方法:

一个共平面波导 (CPW) 装置的调整,用于测试电磁波对SC2-VLP的影响.
用不同频率和电场强度的电磁波对SC2-VLP进行处理.
评估SC2-VLP感染性和与向Spike S1亚单元受体结合域 (RBD) 的抗体的结合亲和力.

主要成果:

用电磁波处理,特别是2.5-3.5 GHz (400V/m2分钟),显著降低了SC2-VLP的感染力.
暴露于3.1 GHz电磁波下降了SC2-VLP与抗体对抗Spike S1 RBD的结合.
这些发现表明,电磁波改变了SARS-CoV-2尖刺蛋白的形状.

结论:

电磁波证明了无效化SARS-CoV-2的概念证明.
这种方法可能适用于针对SARS-CoV-2和其他包裹病毒的卫生和预防策略.
由电磁波改变的Spike蛋白质构造减少了病毒与宿主细胞的附着.

关键词:

一个共平面波导.电磁波是一种电磁波.这就是SARS-CoV-2病毒.卫生设施卫生设施卫生设施斯派克斯派克斯派克斯就是一个尖刺.传输传输传输传输

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