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Updated: Jun 12, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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人类的CCR4-NOT在全球范围内调节基因表达,并且是一种新的逆转移素激活抑制剂

Shardul Kulkarni, Alexis Morrissey, Aswathy Sebastian

    bioRxiv : the preprint server for biology
    |September 24, 2024
    PubMed
    概括

    人类的CCR4-NOT复合体在全球范围内调节基因表达并使可逆转移的元素沉默. 削减关键子单元 CNOT1 和 CNOT4 揭示了 RNA 稳定性和转录中的不同作用,影响 KRAB-Zinc-Finger 蛋白质.

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