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Updated: Jun 17, 2026

Reproducible Mouse Sciatic Nerve Crush and Subsequent Assessment of Regeneration by Whole Mount Muscle Analysis
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在小鼠中自发再生的皮质脊髓神经元

Benjamin W Fait, Bianca Cotto, Tatsuya C Murakami

    bioRxiv : the preprint server for biology
    |September 24, 2024
    PubMed
    概括

    研究人员发现了一种独特的皮质脊髓神经元 (CSN) 类,这些神经元向脊髓的同一侧伸展. 这些自发再生的神经元为脊髓损伤研究提供了新的希望.

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    Neurogenesis and Regeneration of Nervous Tissue01:15

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...